Calcitonin gene–related peptide in migraine: from pathophysiology to treatment
نویسندگان
چکیده
منابع مشابه
Calcitonin gene-related peptide and its role in migraine pathophysiology.
Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from activated trigeminal sensory nerves, dilates intracranial blood vessels and transmits vascular nociception. Therefore, it is propounded that: (i) CGRP may have an important role in migraine pathophysiology, and (ii) inhibition...
متن کاملCalcitonin gene - related peptide and migraine
Recent findings CGRP is widely distributed in the nervous system, particularly at anatomical areas thought to be involved with migraine, including the trigeminovascular nociceptive system. In studies, CGRP has been shown to be released during severe migraine attacks, and effective triptan treatment of an attack normalizes these levels. CGRP administration triggers migraine in patients and CGRP ...
متن کاملCalcitonin gene-related peptide: physiology and pathophysiology.
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30 years ago, it is produced as a consequence of alternative RNA processing of the calcitonin gene. CGRP has two major forms (α and β). It belongs to a group of peptides that all act on an unusual receptor family. These receptors consist of calcitonin receptor-like receptor (CLR) linked to an essential receptor a...
متن کاملCalcitonin gene related peptide (CGRP)-provoked migraine-like attacks.
In this issue of Cephalalgia, Dr Jakob Moller Hansen and his colleagues report a series of very interesting experiments in which they successfully induced migraine-like attacks in patients with migraine with aura via infusion of calcitonin gene related peptide (CGRP). This work echoes similar experiments carried out by the Copenhagen group using the nitric oxide donor, glycerol trinitrate (GTN)...
متن کاملCalcitonin gene-related peptide induced migraine attacks in patients with and without familial aggregation of migraine.
Background Calcitonin gene-related peptide provokes migraine attacks in 65% of patients with migraine without aura. Whether aggregation of migraine in first-degree relatives (family load) or a high number of risk-conferring single nucleotide polymorphisms contributes to migraine susceptibility to calcitonin gene-related peptide infusion in migraine patients is unknown. We hypothesized that gene...
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ژورنال
عنوان ژورنال: Neurología (English Edition)
سال: 2021
ISSN: 2173-5808
DOI: 10.1016/j.nrleng.2019.03.025